Metabolic changes in serum steroids induced by total-body irradiation of female C57B/6 mice
作者: Ju-Yeon MoonHee-June ShinHyun-Hwa SonJeongae LeeUhee JungSung-Kee JoHyun Sik KimKyung-Hoon KwonKyu Hwan ParkBong Chul ChungMan Ho Choi
作者单位: 1Future Convergence Research Division, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea
2Radiation Biotechnology Research Division, Korea Atomic Energy Research Institute, Jeonbuk 580-185, Republic of Korea
3Division of Mass Spectrometry Research, Korea Basic Science Institute, Chungcheongbuk-do 363-883, Republic of Korea
刊名: Journal of Steroid Biochemistry and Molecular Biology, 2014, Vol.141 , pp.52-59
来源数据库: Elsevier Journal
DOI: 10.1016/j.jsbmb.2014.01.004
关键词: AgingGas chromatography–mass spectrometrySteroid signaturesSteroid metabolismTotal-body irradiation
原始语种摘要: Abstract(#br)The short- and long-term effects of a single exposure to gamma radiation on steroid metabolism were investigated in mice. Gas chromatography–mass spectrometry was used to generate quantitative profiles of serum steroid levels in mice that had undergone total-body irradiation (TBI) at doses of 0Gy, 1Gy, and 4Gy. Following TBI, serum samples were collected at the pre-dose time point and 1, 3, 6, and 9 months after TBI. Serum levels of progestins, progesterone, 5β-DHP, 5α-DHP, and 20α-DHP showed a significant down-regulation following short-term exposure to 4Gy, with the exception of 20α-DHP, which was significantly decreased at each of the time points measured. The corticosteroids 5α-THDOC and 5α-DHB...
全文获取路径: Elsevier  (合作)