S5-5 Nucleoside monophosphorothioates as the H 2 S donors in perivascular adipose tissue
作者: Jerzy BełtowskiAndrzej Guranowski
作者单位: 1Department of Pathophysiology, Medical University, Lublin, Poland
2Department of Biochemistry and Biotechnology, Poznań University of Life Sciences, Poznań, Poland
刊名: Nitric Oxide, 2014, Vol.39 , pp.S7-S7
来源数据库: Elsevier Journal
DOI: 10.1016/j.niox.2014.03.025
英文摘要: Background(#br)Adenosine and guanosine 5′-monophosphorothioates (AMPS and GMPS) are synthetic nucleotide analogs with one oxygen atom replaced by sulfur. We have demonstrated that these nucleoside monophosphorothioates (NMPs) are transported to the cell through purinergic receptor/channel P2X 7 and are hydrolyzed to H 2 S by intracellular Hint proteins. Herein we examined if NMPs can serve as the H 2 S donors in vascular wall.(#br)Methods(#br)H 2 S production by isolated tunica media of the rat aorta and periaortic adipose tissue (PAT) was measured in vitro by the polarographic sensor. In addition, effect of NMPs on isometric tension of rat aortic rings with or without PAT was examined.(#br)Results(#br)H 2 S production from NMPs was observed in PAT only in the presence of P2X 7 agonist,...
全文获取路径: Elsevier  (合作)
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影响因子:3.265 (2012)

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