Brain derived neurotropic factor ( BDNF ) is associated with childhood abuse but not cognitive domains in first episode psychosis
作者: Christos TheleritisHelen L. FisherIngo ShäferLaura WintersDaniel StahlCraig MorganPaola DazzanJosefien BreedveltIrene SambathSilia VitoratouManuela RussoAbraham ReichenbergM. Aurora FalconeValeria MondelliJennifer O'ConnorAnthony DavidPhilip McGuireCarmine ParianteMarta Di FortiRobin M. MurrayStefania Bonaccorso
作者单位: 1Dept. of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK
2MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London UK
3Dept. of Psychiatry and Psychotherapy-University Medical Center, Hamburg, Germany
4Biostatistics Department, Institute of Psychiatry, King's College London, London, UK
5Health Services & Population Research Department, Institute of Psychiatry, King's College London, London, UK
6Mount Sinai-Medical School, NY, USA
7Dept. of Psychology, Institute of Psychiatry, King's College London, London, UK
8Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King's College, London, UK
9Section of Perinatal Psychiatry and the Stress, Psychiatry and Immunology Laboratory, Institute of Psychiatry, Department of Psychological Medicine, King's College London, London, UK
刊名: Schizophrenia Research, 2014, Vol.159 (1), pp.56-61
来源数据库: Elsevier Journal
DOI: 10.1016/j.schres.2014.07.013
关键词: BDNFFirst-episode psychosisChildhood traumaCognition
原始语种摘要: Abstract(#br)Background(#br)The Brain-derived Neurotrophic Factor ( BDNF ) modulates cognitive processes and is associated with increased risk of schizophrenia. Childhood trauma (CT) is frequent in patients with psychosis and severely affects course and outcome.(#br)Aims(#br)We investigated the hypothesis that BDNF is associated with both CT and cognitive deficits in a sample of first-episode psychosis (FEP) cases and unaffected controls.(#br)Method(#br)Participants with FEP and healthy controls were recruited between August 2008 and July 2011 from South London, UK. Childhood traumatic events were detected using the Childhood Experience of Care and Abuse Questionnaire (CECA-Q). Neuropsychological data were also collected. BDNF plasma levels were measured from fasting blood...
全文获取路径: Elsevier  (合作)
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影响因子:4.59 (2012)

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