Evolution of glucose utilization: Glucokinase and glucokinase regulator protein
作者: David M. IrwinHuanran Tan
作者单位: 1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
2Banting and Best Diabetes Centre, University of Toronto, Toronto, Canada
3Department of Pharmacology, Peking University, Health Sciences Centre, Beijing, China
刊名: Molecular Phylogenetics and Evolution, 2014, Vol.70 , pp.195-203
来源数据库: Elsevier Journal
DOI: 10.1016/j.ympev.2013.09.016
关键词: Glucokinase (GCK)Hexokinase (HK)Glucokinase regulatory protein (GCKR)LiverGlucose
英文摘要: Abstract(#br)Glucose is an essential nutrient that must be distributed throughout the body to provide energy to sustain physiological functions. Glucose is delivered to distant tissues via be blood stream, and complex systems have evolved to maintain the levels of glucose within a narrow physiological range. Phosphorylation of glucose, by glucokinase, is an essential component of glucose homeostasis, both from the regulatory and metabolic point-of-view. Here we review the evolution of glucose utilization from the perspective of glucokinase. We discuss the origin of glucokinase, its evolution within the hexokinase gene family, and the evolution of its interacting regulatory partner, glucokinase regulatory protein (GCKR). Evolution of the structure and sequence of both glucokinase and GCKR...
全文获取路径: Elsevier  (合作)
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影响因子:4.066 (2012)

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