Trypanocidal activity of organic extracts from the Brazilian and Spanish marine sponges
作者: Jéssica Carreira de PaulaVânia Cristina DesotiEloísa Gibin SampironSolange Cardoso MartinsTânia Ueda-NakamuraSuzi Meneses RibeiroEverson Miguel BiancoSueli de Oliveira SilvaGibson Gomes de OliveiraCelso Vataru Nakamura
作者单位: 1Laboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Maringá, PR, Brazil
2Departamento de Biologia Marinha, Universidade Federal Fluminense, Niterói, RJ, Brazil
3Departamento de Química, Fundação Universidade Regional de Blumenau, Campus I, Blumenau, SC, Brazil
4Laboratório do Núcleo de Pesquisa de Produtos Naturais e Sintéticos da Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil
刊名: Revista Brasileira de Farmacognosia, 2015, Vol.25 (6), pp.651-656
来源数据库: Elsevier Journal
DOI: 10.1016/j.bjp.2015.08.011
关键词: Chagas’ diseaseTrypanosoma cruziNatural productsMarine sponges
原始语种摘要: Abstract(#br)Chagas’ disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affect millions of people worldwide. The available drugs for treatment of this infection cause serious side effects and have variable efficacy, especially in the chronic phase of the disease. In this context, natural compounds have shown great potential for the discovery of new chemotherapies for the treatment of this infection and various other diseases. In present study, we evaluated the in vitro antiprotozoal activity of five species of Brazilian and Spanish marine sponges ( Condrosia reniformes , Tethya rubra , Tethya ignis , Mycale angulosa and Dysidea avara ) against T. cruzi . By GC–MS data, we observed that in these extracts were present the major classes of the following compounds:...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • extracts 摘记
  • ignis 发热
  • trypomastigote 锥虫样鞭毛型
  • antiprotozoal 抗原虫药
  • amastigote 无鞭毛体
  • activity 活度
  • against 反对
  • terpenes 萜烯
  • parasite 寄生物
  • Spanish 西班牙