Vaccination with cyclin-dependent kinase tick antigen confers protection against Ixodes infestation
作者: Helga GomesJorge MoraesNaftaly GithakaRenato MartinsMasayoshi IsezakiItabajara da Silva VazCarlos LogulloSatoru KonnaiKazuhiko Ohashi
作者单位: 1Laboratório Integrado de Bioquímica Hatisaburo Masuda, NUPEM – UFRJ, Campus Macaé, Avenida São José do Barreto, São José do Barreto, Macaé, RJ CEP 27971–220, Brazil
2Tick Vector Laboratory, International Livestock Research Institute, P.O. Box 30709-00100, Nairobi, Kenya
3Laboratório de Química e Função de Proteínas e Peptídeos, Unidade de Experimentação Animal – CBB – UENF, Avenida Alberto Lamego, 2000, Horto, Campos dos Goytacazes RJ, CEP 28015–620, Brazil
4Laboratory of Infectious Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-Ku, Sapporo 060-0818, Japan
5Centro de Biotecnologia e Faculdade de Veterinária, UFRGS, Avenida Bento Gonçalves, 9500, Porto Alegre, RS C.P. 15005, CEP 91501–970, Brazil
6Instituto Nacional de Ciência e Tecnologia – Entomologia Molecular, Rio de Janeiro, RJ, Brazil
7Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, CCS, Bloco H, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil
刊名: Veterinary Parasitology, 2015, Vol.211 (3-4), pp.266-273
来源数据库: Elsevier Journal
DOI: 10.1016/j.vetpar.2015.05.022
关键词: TickVaccineIxodes persulcatusCDKCell cycle
原始语种摘要: Abstract(#br)Among arthropods, ticks lead as vectors of animal diseases and rank second to mosquitoes in transmitting human pathogens. Cyclin-dependent kinases (CDK) participate in cell cycle control in eukaryotes. CDKs are serine/threonine protein kinases and these catalytic subunits are activated or inactivated at specific stages of the cell cycle. To determine the potential of using CDKs as anti-tick vaccine antigens, hamsters were immunized with recombinant Ixodes persulcatus CDK10, followed by a homologous tick challenge. Though it was not exactly unexpected, IpCDK10 vaccination significantly impaired tick blood feeding and fecundity, which manifested as low engorgement weights, poor oviposition, and a reduction in 80% of hatching rates. These findings may underpin the development of...
全文获取路径: Elsevier  (合作)
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影响因子:2.381 (2012)

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