Age-dependent vulnerability of cyclosporine-associated encephalopathy in children
作者: Li-Wen ChenJiann-Shiuh ChenYi-Fang TuShan-Tair WangLan-Wan WangYi-Shan TsaiChao-Ching Huang
作者单位: 1Department of Pediatrics, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan
2Institute of Gerontology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
3Department of Pediatrics, Chi Mei Medical Center, Tainan, Taiwan
4Department of Pediatrics, College of Medicine, Taipei Medical University, Taipei, Taiwan
5Department of Diagnostic Radiology, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan
6Department of Pediatrics, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan
刊名: European Journal of Paediatric Neurology, 2015, Vol.19 (4), pp.464-471
来源数据库: Elsevier Journal
DOI: 10.1016/j.ejpn.2015.02.003
关键词: CyclosporineNeurotoxicity syndromesSeizuresStatus epilepticusAge factorsChild
英文摘要: Abstract(#br)Introduction(#br)Cyclosporine (CsA) is an immunosuppressant known for its neurotoxicity, which presents with acute encephalopathy and seizures in the most severe form. However, whether there is age-related neurological susceptibility in pediatric population is poorly defined. The study aims to examine the vulnerability of CsA neurotoxicity among different age groups of pediatric patients in terms of occurrence rate, acute presentations, long-term outcomes, and neuroimaging findings.(#br)Methods(#br)Pediatric patients (age <18 years) who received CsA in a tertiary referral center between July 1, 1988 and August 31, 2011 were retrospectively reviewed for CsA-related encephalopathy. The clinical presentations, demographic data, and laboratory examinations were analyzed through...
全文获取路径: Elsevier  (合作)
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影响因子:1.982 (2012)

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