Hydrogen sulfide in pharmacology and medicine – An update
作者: Jerzy Bełtowski
作者单位: 1Department of Pathophysiology, Medical University, Lublin, Poland
刊名: Pharmacological Reports, 2015, Vol.67 (3), pp.647-658
来源数据库: Elsevier Journal
DOI: 10.1016/j.pharep.2015.01.005
关键词: Hydrogen sulfideGasotransmittersNon-steroidal anti-inflammatory drugsCardiovascular diseasesInflammation
原始语种摘要: Abstract(#br)Hydrogen sulfide (H 2 S) is the endogenously produced gasotransmitter involved in the regulation of nervous system, cardiovascular functions, inflammatory response, gastrointestinal system and renal function. Together with nitric oxide and carbon monoxide, H 2 S belongs to a family of gasotransmitters. H 2 S is synthesized from l -cysteine and/or l -homocysteine by cystathionine β-synthase, cystathionine γ-lyase and cysteine aminotransferase together with 3-mercaptopyruvate sulfurtransferase. Significant progress has been made in recent years in our understanding of H 2 S biochemistry, signaling mechanisms and physiological role. H 2 S-mediated signaling may be accounted for not only by the intact compound but also by its oxidized form, polysulfides. The most important...
全文获取路径: Elsevier  (合作)
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影响因子:1.965 (2012)

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