Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic–pituitary–adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life
作者: Hui-Feng ChenHui-Min Su
作者单位: 1Department of Physiology, National Taiwan University College of Medicine, No. 1, Sec. 1, Jen-Ai Rd, Taipei, 100, Taiwan
刊名: The Journal of Nutritional Biochemistry, 2013, Vol.24 (1), pp.70-80
来源数据库: Elsevier Journal
DOI: 10.1016/j.jnutbio.2012.02.006
关键词: HypothalamusStressBrain developmentn-3 fatty acidsDocosahexaenoic acid (DHA)HPA axisCorticosteroneGamma-aminobutyric acid A (GABA A )GAD67DepressionAnxiety
原始语种摘要: Abstract(#br)Brain docosahexaenoic acid (DHA, 22:6n-3) accumulates rapidly during brain development and is essential for normal neurological function. The aim of this study was to evaluate whether brain development was the critical period in which DHA deficiency leads to dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis in response to stress later in life. Rats were exposed to an n-3 fatty acid-deficient diet or the same diet supplemented with fish oil as an n-3 fatty acid-adequate diet either throughout the preweaning period from embryo to weaning at 3 weeks old or during the postweaning period from 3 to 10 weeks old. Exposure to the n-3 fatty acid-deficient diet during the preweaning period resulted, at weaning, in a significant decrease in hypothalamic DHA levels and a...
全文获取路径: Elsevier  (合作)
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影响因子:4.552 (2012)

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