Dose-dependent effect of donepezil administration on long-term enhancement of visually evoked potentials and cholinergic receptor overexpression in rat visual cortex
作者: Mira ChamounMarianne GroleauMenakshi BhatElvire Vaucher
作者单位: 1Laboratoire de Neurobiologie de la Cognition Visuelle, École d’optométrie, Université de Montréal, Montréal, Québec, Canada
刊名: Journal of Physiology - Paris, 2016, Vol.110 (1-2), pp.65-74
来源数据库: Elsevier Journal
DOI: 10.1016/j.jphysparis.2016.11.010
关键词: Cholinergic enhancementAcetylcholinesterase inhibitorsCortical activityMuscarinic receptorsNicotinic receptorsVisual cortex
英文摘要: Abstract(#br)Stimulation of the cholinergic system tightly coupled with periods of visual stimulation boosts the processing of specific visual stimuli via muscarinic and nicotinic receptors in terms of intensity, priority and long-term effect. However, it is not known whether more diffuse pharmacological stimulation with donepezil, a cholinesterase inhibitor, is an efficient tool for enhancing visual processing and perception. The goal of the present study was to potentiate cholinergic transmission with donepezil treatment (0.5 and 1mg/kg) during a 2-week visual training to examine the effect on visually evoked potentials and to profile the expression of cholinergic receptor subtypes. The visual training was performed daily, 10min a day, for 2...
全文获取路径: Elsevier  (合作)
影响因子:0.815 (2012)