Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 ( TRPC3 ) gene and postoperative analgesic requirements
作者: Yoshinori AokiDaisuke NishizawaJunko HasegawaShinya KasaiKaori YoshidaYoshihiko KoukitaTatsuya IchinoheMakoto NagashimaRyoji KatohYasuo SatohMegumi TagamiMasakazu HayashidaKen-ichi FukudaKazutaka Ikeda
作者单位: 1Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan
2Department of Dental Anesthesiology, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan
3Department of Surgery, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan
4Department of Anesthesiology, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan
5Department of Anesthesiology, Juntendo University, 3-1-3 Hongou, Bunkyo-ku, Tokyo 113-8431, Japan
刊名: Journal of Pharmacological Sciences, 2015, Vol.127 (3), pp.391-393
来源数据库: Elsevier Journal
DOI: 10.1016/j.jphs.2015.02.005
关键词: TRPC3AnalgesicsPolymorphism
英文摘要: Abstract(#br)An association between postoperative analgesic requirements in subjects who underwent orthognathic surgery and the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 ( TRPC3 ) gene was suggested by our previous genome-wide association study. To verify this association, we analyzed the association between the rs1465040 SNP and analgesic requirements, including opioid requirements, after open abdominal surgery. The association between the rs1465040 SNP and postoperative analgesic requirements was confirmed in the open abdominal surgery group ( P = 0.036), suggesting that the TRPC3 SNP may contribute to predicting postoperative analgesic requirements.
全文获取路径: Elsevier  (合作)
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影响因子:2.15 (2012)

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