Evaluation of TSPO PET imaging, a marker of glial activation, to study the neuroimmune footprints of morphine exposure and withdrawal
作者: Sylvain AuvitySébastien GoutalBenoît ThézéCatarina ChavesBenoît HostenBertrand KuhnastWadad SabaRaphaël BoisgardIrène BuvatSalvatore CisterninoNicolas Tournier
作者单位: 1Variabilité de la Réponse aux Psychotropes, INSERM U1144, Paris F-75006, France
2Université Paris Descartes, UMR-S 1144, Paris F-75006, France
3Université Paris Diderot, UMR-S 1144, Paris F-75013, France
4Imagerie Moléculaire In Vivo, IMIV, CEA, Inserm, CNRS, Univ. Paris-Sud, Université Paris Saclay, CEA-SHFJ, Orsay F-91401, France
5REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal
6Assistance publique hôpitaux de Paris, AP-HP, Paris F-75004, France
刊名: Drug and Alcohol Dependence, 2017, Vol.170 , pp.43-50
来源数据库: Elsevier Journal
DOI: 10.1016/j.drugalcdep.2016.10.037
关键词: MicrogliaOpioidAddictionToleranceDPA-714Neuroinflammation
原始语种摘要: Abstract(#br)Introduction(#br)A growing area of research suggests that neuroimmunity may impact the pharmacology of opioids. Microglia is a key component of the brain immunity. Preclinical and clinical studies have demonstrated that microglial modulators may improve morphine-induced analgesia and prevent the development of tolerance and dependence. Positron emission tomography (PET) using translocator protein 18kDa (TSPO) radioligand is a clinically validated strategy for the non-invasive detection of microglial activation. We hypothesized that TSPO PET imaging may be used to study the neuroimmune component of opioid tolerance and withdrawal.(#br)Methods(#br)Healthy rats (n=6 in each group) received either saline or escalating doses...
全文获取路径: Elsevier  (合作)
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来源刊物:
影响因子:3.141 (2012)

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关键词翻译
关键词翻译
  • morphine 吗啡
  • withdrawal 取消
  • glial 神经胶质的
  • imaging 图像形成
  • activation 活化
  • radioligand 放射性配体
  • metabolite 蚀变粗玻岩
  • pharmacology 药理学
  • opioid 鸦片样物质
  • brain