A conjugated fatty acid present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD + /NADH ratio and activating PPARα, AMPK and SIRT1 signaling pathway
作者: Gou-Chun ChenHui-Min SuYu-Shun LinPo-Yen TsouJong-Ho ChyuanPei-Min Chao
作者单位: 1Department of Nutrition, China Medical University, Taichung, Taiwan
2Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan
3Hualien District Agricultural Research and Extension Station, Hualien, Taiwan
刊名: The Journal of Nutritional Biochemistry, 2016, Vol.33 , pp.28-35
来源数据库: Elsevier Journal
DOI: 10.1016/j.jnutbio.2016.03.009
关键词: α-Eleostearic acidPPARαAMP-activated protein kinaseSirtuin-1H4IIEC3 cellsNicotinamide phosphoribosyltransferase
英文摘要: Abstract(#br)α-Eleostearic acid (α-ESA), or the cis -9, trans -11, trans -13 isomer of conjugated linolenic acid, is a special fatty acid present at high levels in bitter melon seed oil. The aim of this study was to examine the effect of α-ESA on hepatic lipid metabolism. Using H4IIEC3 hepatoma cell line, we showed that α-ESA significantly lowered intracellular triglyceride accumulation compared to α-linolenic acid (LN), used as a fatty acid control, in a dose- and time-dependent manner. The effects of α-ESA on enzyme activities and mRNA profiles in H4IIEC3 cells suggested that enhanced fatty acid oxidation and lowered lipogenesis were involved in α-ESA-mediated triglyceride lowering effects. In addition, α-ESA triggered AMP-activated protein kinase (AMPK) activation without altering...
全文获取路径: Elsevier  (合作)
影响因子:4.552 (2012)