CaCO 3 nanoparticles as an ultra-sensitive tumor-pH-responsive nanoplatform enabling real-time drug release monitoring and cancer combination therapy
作者: Ziliang DongLiangzhu FengWenwen ZhuXiaoqi SunMin GaoHe ZhaoYu ChaoZhuang Liu
作者单位: 1Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, 199 Ren'ai Road, Suzhou, 215123, Jiangsu, PR China
2Department of Radiology, Children's Hospital of Soochow University, Suzhou, 215003, Jiangsu, PR China
刊名: Biomaterials, 2016, Vol.110 , pp.60-70
来源数据库: Elsevier Journal
DOI: 10.1016/j.biomaterials.2016.09.025
关键词: CaCO 3 nanoparticlepH-sensitiveMR imagingReal-time monitoringCancer combination therapy
英文摘要: Abstract(#br)The exploration of stimuli-responsive nano-theranostics provides powerful tools for simultaneously enhancing the accuracy and efficiency of cancer therapies. Herein, we develop mono-dispersed CaCO 3 nanoparticles modified with polyethylene glycol (PEG) as a multifunctional nano-carrier for efficient loading of both Mn 2+ -chelated chlorin e6 (Ce6(Mn)) as a photosensitizer, and doxorubicin (DOX) as a chemotherapy drug. Our CaCO 3 @Ce6(Mn)-PEG(DOX) nanoparticles, while being stable under physiological pH at 7.4, appear to be highly sensitive to reduced pH and would be rapidly degraded under slightly acidic environment, effectively releasing loaded therapeutic agents. Interestingly, owing to released Ce6(Mn), those nanoparticles show an interesting pH-dependent T1 signal...
全文获取路径: Elsevier  (合作)
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影响因子:7.604 (2012)

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