P13 S-Propargyl-Cysteine (SPRC) promoted angiogenesis under both normal and ischemic conditions: Possible STAT3-mediated mechanism
作者: Juntao KanWei GuoChengrong HuangYizhun Zhu
作者单位: 1School of Pharmacy, Fudan University, Shanghai 201203, China
2Institutes of Biomedical Science, Fudan University, Shanghai 201203, China
刊名: Nitric Oxide, 2012, Vol.27 , pp.S16-S17
来源数据库: Elsevier Journal
DOI: 10.1016/j.niox.2012.08.014
英文摘要: Background(#br)In most western countries, ischemic heart disease (IHD) is the most common cause of death and a major cause of hospital admissions. Conventional drug therapy is designed to effect through anti-oxidation, anti-apoptosis, anti-inflammation and anti-lipidemia to protect against IHD. Since hydrogen sulfide has been reported to induce angiogenesis in vitro and in vivo , we investigated the pro-angiogenic effect of SPRC, a novel water-soluble modulator of endogenous hydrogen sulfide, to provide experimental basis for angiogenesis-mediated drug therapy of IHD. In addition, we revealed STAT3-mediated mechanism involved in hydrogen sulfide-induced angiogenesis.(#br)Methods(#br)Cell viability assay, cell proliferation assay, cell adhesion assay, wound healing assay, transwell...
全文获取路径: Elsevier  (合作)
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影响因子:3.265 (2012)

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