Resveratrol as a calorie restriction mimetic: therapeutic implications
作者: Jay H. ChungVincent ManganielloJason R.B. Dyck
作者单位: 1Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
2Cardiovascular Pulmonary Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
3Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, Department of Pediatrics, University of Alberta, Edmonton, Canada T6G 2S2
刊名: Trends in Cell Biology, 2012, Vol.22 (10), pp.546-554
来源数据库: Elsevier Journal
DOI: 10.1016/j.tcb.2012.07.004
关键词: resveratrolPDEAMPKSirt1calorie restrictiondiabetes
原始语种摘要: It is widely believed that calorie restriction (CR) can extend the lifespan of model organisms and protect against aging-related diseases. A potential CR mimetic is resveratrol, which may have beneficial effects against numerous diseases such as type 2 diabetes, cardiovascular diseases, and cancer in tissue culture and animal models. However, resveratrol in its current form is not ideal as therapy, because even at very high doses it has modest efficacy and many downstream effects. Identifying the cellular targets responsible for the effects of resveratrol and developing target-specific therapies will be helpful in increasing the efficacy of this drug without increasing its potential adverse effects. A recent discovery suggests that the metabolic effects of resveratrol may be mediated by...
全文获取路径: Elsevier  (合作)
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影响因子:11.721 (2012)

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