A maternal high n-6 fat diet with fish oil supplementation during pregnancy and lactation in rats decreases breast cancer risk in the female offspring
作者: Hui-Min SuPei-Hsuan HsiehHui-Feng Chen
作者单位: 1Department of Physiology, National Taiwan University College of Medicine, Taipei 100, Taiwan
刊名: The Journal of Nutritional Biochemistry, 2009, Vol.21 (11), pp.1033-1037
来源数据库: Elsevier Journal
DOI: 10.1016/j.jnutbio.2009.08.007
关键词: Breast cancerHigh-fat dietn-6 fatty acidsFish oilLife stageEstradiol
原始语种摘要: Abstract(#br)The timing of dietary fat intake may modify breast cancer risk. In addition, n-3 fatty acids reduce, and n-6 fatty acids increase, the risk of breast cancer and a maternal high n-6 fat diet results in a greater risk of breast cancer in the female offspring. We hypothesized that the timing of n-3 fatty acid-enriched fish oil supplementation would be important for reducing the risk of breast cancer. Female rats were fed to a high n-6 fat diet containing 20% of the sunflower oil by weight during pregnancy and lactation, and the female offspring were exposed to fish oil by oral gavage either during the perinatal period via maternal intake or during puberty or adulthood. Exposure during the perinatal period to a maternal high n-6 fat diet with fish oil supplementation...
全文获取路径: Elsevier  (合作)
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影响因子:4.552 (2012)

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