Cis -9, trans -11, trans -13-conjugated linolenic acid induces apoptosis and sustained ERK phosphorylation in 3T3-L1 preadipocytes
作者: Yi-Chun ChouHui-Min SuTzu-Wen LaiJong-Ho ChyuanPei-Min Chao
作者单位: 1Division of Nutritional Science, Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, Taipei, Taiwan
2Institute of Nutrition, China Medical University, Taichung, Taiwan
3Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan
4Hualien District Agricultural Research and Extension Station, Hualien, Taiwan
刊名: Nutrition, 2012, Vol.28 (7-8), pp.803-811
来源数据库: Elsevier Journal
DOI: 10.1016/j.nut.2011.11.019
关键词: Cis -9trans -11trans -13 onjugated linolenic acidLinolenic acidAdipogenesis3T3-L1ERK/MAPK
英文摘要: Abstract(#br)Objective(#br)The aim of this study was to investigate the adipogenic effect of cis -9, trans -11, trans -13-conjugated linolenic acid ( c 9, t 11, t 13 - CLN), a fatty acid naturally present in bitter melon.(#br)Methods(#br)The 3T3-L1 murine preadipocyte cell line was used to test the effect of saponifiables from whole bitter melon and of commercially prepared pure c 9 ,t 11 ,t 13 - CLN on adipocyte differentiation. The effect of c 9 ,t 11 ,t 13 - CLN on 3T3-L1 cell viability was also tested at proliferation, mitotic clonal expansion, and terminal differentiation stages.(#br)Results(#br)Compared to the free fatty acid control mixture, the proadipogenic effect on 3T3-L1 was less potent using saponifiables obtained from bitter melon. C 9 ,t 11 ,t 13 - CLN, unlike its...
全文获取路径: Elsevier  (合作)
影响因子:2.859 (2012)