Preparation of α-functionalized alkenylmagnesium reagents via a halide–magnesium exchange
作者: Jérôme ThibonnetViet Anh VuLaurent BérillonPaul Knochel
作者单位: 1Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, D-81377 München, Germany
刊名: Tetrahedron, 2002, Vol.58 (24), pp.4787-4799
来源数据库: Elsevier Journal
DOI: 10.1016/S0040-4020(02)00439-8
关键词: magnesiumfunctionalized Grignard reagentsnitrilesulfone
原始语种摘要: Abstract(#br)A general preparation of alkenylmagnesium derivatives bearing an electron-withdrawing function in the α-position (Y=CN, CO 2 R, CONR 2 , SO 2 Ph) has been made possible by using a low temperature (−40 to −30°C) bromine–magnesium exchange with i -PrMgBr in THF. This reaction has also been used to prepare 5-magnesiated-1,3-dioxin-4-one derivatives bearing an alkoxy substituent in β-position to the carbon–magnesium bond.
全文获取路径: Elsevier  (合作)
影响因子:2.803 (2012)