XPA A23G, XPC Lys939Gln, XPD Lys751Gln and XPD Asp312Asn polymorphisms, interactions with smoking, alcohol and dietary factors, and risk of colorectal cancer
作者: Rikke Dalgaard HansenMette SørensenAnne TjønnelandKim OvervadHåkan WallinOle Raaschou-NielsenUlla Vogel
作者单位: 1National Research Centre for the Working Environment, Lersø Parkalle 105, 2100 Copenhagen, Denmark
2Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
3Department of Clinical Epidemiology, Aalborg Hospital, Stengade 10, Postbox 561, 9100 Aalborg, Denmark
刊名: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2007, Vol.619 (1), pp.68-80
来源数据库: Elsevier Journal
DOI: 10.1016/j.mrfmmm.2007.02.002
关键词: Colorectal cancerNucleotide excision repairGene–environment interactionsAlcoholSmokingRed meat and processed meat
原始语种摘要: Abstract(#br)Polymorphisms in the XPD and the XPC gene have been associated with a lower DNA repair capacity. We determined the risk of colorectal cancer in association with the four polymorphisms XPA A23G, XPC Lys939Gln, XPD Lys751Gln and XPD Asp312Asn, and interactions between the polymorphisms and the environmental factors: smoking intensity, intake of alcohol, red meat, processed meat, fish and poultry, fruits and vegetables and dietary fibres, in relation to development of colorectal cancer in a study population of 405 colorectal cancer cases and a comparison group of 810 persons, nested within the Danish prospective cohort, Diet, Cancer and Health, of 57053 cohort members. No association was found between the XPC Lys939Gln, XPA A23G, XPD Lys751Gln, and XPD...
全文获取路径: Elsevier  (合作)