Azithromycin Therapy in Hospitalized Infants with Acute Bronchiolitis is Not Associated with Better Clinical Outcomes: A Randomized, Double-Blinded, and Placebo-Controlled Clinical Trial
作者: Leonardo A. PintoPaulo M. PitrezFernanda LuisiPatricia Piccoli de MelloMoisés GerhardtRoberta FerliniDaniel Cardoso BarbosaIvana DarosMarcus H. JonesRenato T. SteinPaulo J. Marostica
作者单位: 1Department of Pediatrics, Hospital São Lucas and Institute of Biomedical Research, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
2Department of Pediatrics, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
刊名: The Journal of Pediatrics, 2012, Vol.161 (6), pp.1104-1108
来源数据库: Elsevier Journal
DOI: 10.1016/j.jpeds.2012.05.053
英文摘要: Objective(#br)To test the hypothesis that azithromycin reduces the length of hospitalization and oxygen requirement in infants with acute viral bronchiolitis (AB).(#br)Study design(#br)We performed a randomized, double-blinded, placebo-controlled trial in southern Brazil, from 2009 to 2011. Infants (<12 months of age) hospitalized with AB were recruited in 2 hospitals. Patients were randomized to receive either azithromycin or placebo, administered orally, for 7 days. At enrollment, clinical data were recorded and nasopharyngeal samples were collected for viral identification through immunofluorescence. Main outcomes were duration of oxygen requirement and length of hospitalization.(#br)Results(#br)One hundred eighty-four patients were included in the study (azithromycin 88 subjects,...
全文获取路径: Elsevier  (合作)
影响因子:4.035 (2012)