Aberrant expression of HMB-45 in traumatized melanocytic nevi
作者: Todd M. LeleuxVictor G. PrietoA. Hafeez Diwan
作者单位: 1Departments of Pathology & Immunology and Dermatology, Baylor College of Medicine, Houston, Texas
2Department of Pathology, University of Texas, MD Anderson Cancer Center, Houston, Texas
刊名: Journal of the American Academy of Dermatology, 2012, Vol.67 (3), pp.446-450
来源数据库: Elsevier Journal
DOI: 10.1016/j.jaad.2011.11.927
关键词: HMB-45Ki-67melanocytic nevitrauma
英文摘要: Background(#br)Assessment of histologic and immunohistochemical maturation (with HMB-45 and anti-Ki-67) may be helpful in differentiating benign melanocytic nevi (BMN) from malignant melanoma. Recently, we reported loss of maturation and aberrant immunohistochemical findings in melanocytic nevi after liquid nitrogen cryotherapy (Adeniran et al, J Am Acad Dermatol 2009;61:341-5). Herein we report a similar phenomenon identified in traumatized melanocytic nevi (TMN).(#br)Objective(#br)We sought to evaluate the histologic and immunohistochemical findings in early and late stages of traumatized nevi.(#br)Methods(#br)Twenty-four cases of TMN were retrieved from the pathology archives. These were then assessed by two pathologists (T.L. and A.H.D.) using HMB-45 and MIB-1 (for Ki-67)...
全文获取路径: Elsevier  (合作)