Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1
作者: Yaoming WangZhen ZhaoNienwen ChowTracy AliJohn H. GriffinBerislav V. Zlokovic
作者单位: 1Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
2Center for Neurodegenerative and Vascular Brain Disorders and Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
3ZZ Biotech L.L.C., Rochester, NY 14642, USA
4Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
刊名: Brain Research, 2013, Vol.1507 , pp.97-104
来源数据库: Elsevier Journal
DOI: 10.1016/j.brainres.2013.02.023
关键词: 3K3A-APCStrokeNeurogenesisNeuroprotectionProtease activated receptor 1
原始语种摘要: Abstract(#br)3K3A-APC is a recombinant analog of activated protein C (APC) which is an endogenous protease with multiple functions in the body. Compared to APC, 3K3A-APC has reduced anticoagulant activity but preserved cell signaling activities. In the brain, 3K3A-APC exerts neuroprotective effects after an acute or chronic injury. 3K3A-APC is currently under clinical assessment as a neuroprotective agent following acute ischemic stroke. Whether 3K3A-APC can influence post-ischemic neurogenesis and improve neurological outcome by promoting brain repair remains unknown. Here we show that murine 3K3A-APC 0.8mg/kg intraperitoneally given at 12h, 1, 3, 5 and 7 days after permanent distal middle cerebral artery occlusion (dMCAO) in mice compared to vehicle...
全文获取路径: Elsevier  (合作)
影响因子:2.879 (2012)