Nucleoside monophosphorothioates as the new hydrogen sulfide precursors with unique properties
作者: Jerzy BełtowskiAndrzej GuranowskiAnna Jamroz-WiśniewskaAgnieszka KorolczukAndrzej Wojtak
作者单位: 1Department of Pathophysiology, Medical University, Lublin, Poland
2Department of Biochemistry and Biotechnology, Poznań University of Life Sciences, Poznań, Poland
3Department of Neurology, Medical University, Lublin, Poland
4Department of Pathomorphology, Medical University, Lublin, Poland
5Department of Vascular Surgery, Medical University, Lublin, Poland
刊名: Pharmacological Research, 2014, Vol.81 , pp.34-43
来源数据库: Elsevier Journal
DOI: 10.1016/j.phrs.2014.01.003
关键词: Hydrogen sulfideNucleoside phosphorothioatesHint proteinsP2X 7 receptorAdenosineAMP-stimulated protein kinase
原始语种摘要: Abstract(#br)Hydrogen sulfide (H 2 S) is the gasotransmitter enzymatically synthesized in mammalian tissues from l -cysteine. H 2 S donors are considered as the potential drugs for the treatment of cardiovascular, neurological and inflammatory diseases. Recently, it has been demonstrated that synthetic nucleotide analogs, adenosine- and guanosine 5′-monophosphorothioates (AMPS and GMPS) can be converted to H 2 S and AMP or GMP, respectively, by purified histidine triad nucleotide-binding (Hint) proteins. We examined if AMPS and GMPS can be used as the H 2 S donors in intact biological systems. H 2 S production by isolated rat kidney glomeruli was measured by the specific polarographic sensor. H 2 S production was detected when glomeruli were incubated with AMPS or GMPS and ionotropic...
全文获取路径: Elsevier  (合作)
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影响因子:4.346 (2012)

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