Thyroid hormone exacerbates vasoconstriction in insulin resistance: The role of ONOO −
作者: D.H. HuJ. PengX. ZhangH.L. ZhengS.M. YanY.T. ZhangQ.H. GuanQ.L. Ding
作者单位: 1Experimental and Teaching Center of Medical Basis for Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China
刊名: European Journal of Pharmacology, 2014, Vol.730 , pp.41-50
来源数据库: Elsevier Journal
DOI: 10.1016/j.ejphar.2014.02.018
关键词: Insulin resistanceHyperthyroidismVasoconstrictionPeroxynitrite ion
原始语种摘要: Abstract(#br)Insulin resistance has been proposed to play a pivotal role in vasoconstriction due to increased oxidative stress. Hyperthyroidism would amplify cardiovascular disease risk in diabetic patients, though thyroid hormone advance vascular relaxation and reduce vascular contraction by virtue of NO production in vascular smooth muscle cells (VSMCs). Thus, we aimed to investigate the vascular tone and its underlying mechanism in insulin resistance accompanied by hyperthyroidism. Vascular reactivity studies showed that endothelium-denuded thoracic aortic rings from rats fed with high-fat high-sucrose (HFHS) diet and L-T 4 (HFHS+L-T 4 ) exhibited a stronger contractile response to noradrenaline than HFHS rats, which was reversed by L-NAME and GSH. Furthermore, rat thoracic aortic...
全文获取路径: Elsevier  (合作)
影响因子:2.592 (2012)

  • insulin 胰岛素
  • hormone 激素
  • vascular 维管的
  • resistance 抵抗
  • oxidative 氧化的
  • diabetic 糖尿病患者
  • thoracic 胸的
  • aortic 织脉的
  • muscle 肌肉
  • glucose 葡萄糖