Impact of Mechanical Activation, Scar, and Electrical Timing on Cardiac Resynchronization Therapy Response and Clinical Outcomes
作者: Kenneth C. BilchickSujith KuruvillaYasmin S. HamiraniRaghav RamachandranSamantha A. ClarkeKatherine M. ParkerGeorge J. StukenborgPamela MasonJohn D. FergusonJ. Randall MoormanRohit MalhotraJ. Michael MangrumAndrew E. DarbyJohn DiMarcoJeffrey W. HolmesMichael SalernoChristopher M. KramerFrederick H. Epstein
作者单位: 1Department of Medicine, Cardiovascular Division, University of Virginia Health System, Charlottesville, Virginia
2Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia
3Department of Public Health Sciences, University of Virginia Health System, Charlottesville, Virginia
4Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia
刊名: Journal of the American College of Cardiology, 2014, Vol.63 (16), pp.1657-1666
来源数据库: Elsevier Journal
DOI: 10.1016/j.jacc.2014.02.533
关键词: cardiac magnetic resonancecardiac resynchronization therapyheart failuremyocardial infarctionventricular tachycardia
英文摘要: Objectives(#br)Using cardiac magnetic resonance (CMR), we sought to evaluate the relative influences of mechanical, electrical, and scar properties at the left ventricular lead position (LVLP) on cardiac resynchronization therapy (CRT) response and clinical events.(#br)Background(#br)CMR cine displacement encoding with stimulated echoes (DENSE) provides high-quality strain for overall dyssynchrony (circumferential uniformity ratio estimate [CURE] 0 to 1) and timing of onset of circumferential contraction at the LVLP. CMR DENSE, late gadolinium enhancement, and electrical timing together could improve upon other imaging modalities for evaluating the optimal LVLP.(#br)Methods(#br)Patients had complete CMR studies and echocardiography before CRT. CRT response was defined as a 15% reduction...
全文获取路径: Elsevier  (合作)
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影响因子:14.086 (2012)

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