Sex differences in diurnal rhythms of food intake in mice caused by gonadal hormones and complement of sex chromosomes
作者: Xuqi ChenLixin WangDawn H. LohChristopher S. ColwellYvette TachéKaren ReueArthur P. Arnold
作者单位: 1Department of Integrative Biology & Physiology, University of California, Los Angeles, CA, USA
2Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA, USA
3CURE/Digestive Diseases Research Center and Center for the Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
4VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Los Angeles, CA, 90073, USA
5Department of Psychiatry and Biobehavioral Sciences, Semel Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
6Department of Human Genetics and Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles CA, USA
刊名: Hormones and Behavior, 2015, Vol.75 , pp.55-63
来源数据库: Elsevier Journal
DOI: 10.1016/j.yhbeh.2015.07.020
关键词: Food intakeSex differencesTestosteroneEstradiolSex chromosomesFour Core GenotypesBody compositionCircadian rhythmNight eatingObesityAdiposity
原始语种摘要: Abstract(#br)We measured diurnal rhythms of food intake, as well as body weight and composition, while varying three major classes of sex-biasing factors: activational and organizational effects of gonadal hormones, and sex chromosome complement (SCC). Four Core Genotypes (FCG) mice, comprising XX and XY gonadal males and XX and XY gonadal females, were either gonad-intact or gonadectomized (GDX) as adults (2.5months); food intake was measured second-by-second for 7days starting 5weeks later, and body weight and composition were measured for 22weeks thereafter. Gonadal males weighed more than females. GDX increased body weight/fat of gonadal females, but increased body fat and reduced body weight of males. After...
全文获取路径: Elsevier  (合作)
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影响因子:3.735 (2012)

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