Efficient synthesis of novel pyrano[2,3- d ]pyrido[1,2- a ]pyrimidine derivatives via isocyanide-based three-component reactions
作者: Abbas Ali EsmaeiliFariba SalehanAzizollah HabibiAli Reza Fakhari
作者单位: 1Department of Chemistry, Ferdowsi University of Mashhad, Mashhad, Iran
2Faculty of Chemistry, Kharazmi University, No. 49, Mofateh Ave., Tehran, Iran
3Department of Chemistry, Faculty of Sciences, Shahid Beheshti University, G.C., PO Box 19396-4716, Evin, Tehran, Iran
刊名: Tetrahedron Letters, 2016, Vol.57 (1), pp.100-102
来源数据库: Elsevier Journal
DOI: 10.1016/j.tetlet.2015.11.073
关键词: Multi-component reactionPyranopyridopyrimidineAcetylenic estersAlkyl isocyanideOne-pot synthesis
英文摘要: Abstract(#br)The synthesis of novel tricyclic fused pyrano[2,3- d ]pyrido[1,2- a ]pyrimidines containing both biologically active pyridopyrimidine and pyranopyrimidine scaffolds, via the reaction of 2 H -pyrido[1,2- a ]pyrimidine-2,4(3 H )-dione, isocyanides, and dialkylacetylenedicarboxylates are reported. The products were obtained in good to excellent yields over short reaction times and with a simple work-up procedure.
全文获取路径: Elsevier  (合作)
影响因子:2.397 (2012)