Clinical and laboratory studies of 17 patients with acute myeloid leukemia harboring t (7;11)(p15;p15) translocation
作者: Shuning WeiSiping WangShaowei QiuJunyuan QiYingchang MiDong LinChunlin ZhouBingcheng LiuWei LiYing WangMin WangJianxiang Wang
作者单位: 1Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 288 Nanjing Road, Tianjin 300020, China
刊名: Leukemia Research, 2013, Vol.37 (9), pp.1010-1015
来源数据库: Elsevier Journal
DOI: 10.1016/j.leukres.2013.05.020
关键词: TranslocationNUP98 – HOXA9LeukemiaMyeloidAcutet (711)(p15p15)
原始语种摘要: Abstract(#br)The cellular and molecular genetic aberrations of hematopoietic and lymphoid tissues are increasingly important in leukemia classification and are prognostically significant. Although some recurrent molecular cytogenetic abnormalities in AML have been extensively studied, others including t (7;11)(p15;p15) have not been well characterized. In this paper, seventeen AML patients with t (7;11)(p15;p15) were retrospectively reviewed for cell morphology, immuno-phenotype, cytogenetics as well as clinical features and prognosis. Among them, thirteen were female; nine were AML-M2. Six patients who were newly diagnosed were alive, one was lost for followed up and ten died. The median survival was 8 months. Taking together, AML with t (7;11)(p15;p15) is a rare and distinct disease....
全文获取路径: Elsevier  (合作)
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影响因子:2.764 (2012)

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