Genetic ablation of carotene oxygenases and consumption of lycopene or tomato powder diets modulate carotenoid and lipid metabolism in mice
作者: Nikki A. FordAmy C. ElsenJohn W. Erdman
作者单位: 1Department of Nutritional Sciences, University of Texas at Austin, Austin TX 78723, USA
2Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA
3Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA
刊名: Nutrition Research, 2013, Vol.33 (9), pp.733-742
来源数据库: Elsevier Journal
DOI: 10.1016/j.nutres.2013.07.007
关键词: LycopenePhytoeneTomatoLipidsCholesterolCMO-ICMO-IIMice
原始语种摘要: Abstract(#br)Carotene-15,15′-monooxygenase (CMO-I) cleaves β -carotene to form vitamin A, whereas carotene-9′,10′-monooxygenase (CMO-II) preferentially cleaves non–provitamin A carotenoids. Recent reports indicate that β -carotene metabolites regulate dietary lipid uptake, whereas lycopene regulates peroxisome proliferator-activated receptor expression. To determine the physiologic consequences of carotenoids and their interactions with CMO-I and CMO-II, we characterized mammalian carotenoid metabolism, metabolic perturbations, and lipid metabolism in female CMO-I −/− and CMO-II −/− mice fed lycopene or tomato-containing diets for 30 days. We hypothesized that there would be significant interactions between diet and genotype on carotenoid accumulation and lipid parameters. CMO-I −/− mice...
全文获取路径: Elsevier  (合作)
影响因子:2.142 (2012)