Current Evidence and Future Perspectives on HuR and Breast Cancer Development, Prognosis, and Treatment
作者: Ioly Kotta-LoizouSpyridon N. VasilopoulosRobert H.A. CouttsStamatios Theocharis
作者单位: 1Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, United Kingdom
2First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece
3Geography, Environment and Agriculture Division, Department of Biological and Environmental Sciences, School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, United Kingdom
刊名: Neoplasia, 2016, Vol.18 (11), pp.674-688
来源数据库: Elsevier Journal
DOI: 10.1016/j.neo.2016.09.002
英文摘要: Abstract(#br)Hu-antigen R (HuR) is an RNA-binding posttranscriptional regulator that belongs to the Hu/ELAV family. HuR expression levels are modulated by a variety of proteins, microRNAs, chemical compounds, or the microenvironment, and in turn, HuR affects mRNA stability and translation of various genes implicated in breast cancer formation, progression, metastasis, and treatment. The aim of the present review is to critically summarize the role of HuR in breast cancer development and its potential as a prognosticator and a therapeutic target. In this aspect, all the existing English literature concerning HuR expression and function in breast cancer cell lines, in vivo animal models, and clinical studies is critically presented and summarized. HuR modulates many genes implicated in...
全文获取路径: Elsevier  (合作)
影响因子:5.47 (2012)