Beneficial effect of bilingualism on Alzheimer's disease CSF biomarkers and cognition
作者: Ainara EstangaMirian Ecay-TorresAlmudena IbañezAndrea IzagirreJorge VillanuaMaite Garcia-SebastianM. Teresa Iglesias GasparAne Otaegui-ArrazolaAne IriondoMonserrat CleriguePablo Martinez-Lage
作者单位: 1Department of Neurology, CITA-Alzheimer Foundation, San Sebastian, Spain
2Department of Neuroimaging, CITA-Alzheimer Foundation, San Sebastian, Spain
3Donostia Unit, Osatek SA, Donostia University Hospital, San Sebastian, Spain
4Clinical Epidemiology Unit, Donostia University Hospital, Biodonostia, CIBER-ESP, San Sebastian, Spain
刊名: Neurobiology of Aging, 2017, Vol.50 , pp.144-151
来源数据库: Elsevier Journal
DOI: 10.1016/j.neurobiolaging.2016.10.013
关键词: BilingualismPreclinical Alzheimer's diseaseCSF biomarkersCognitive performanceCognitive/brain reserveCohort studies
英文摘要: Abstract(#br)Bilingualism as a component of cognitive reserve has been claimed to delay the onset of Alzheimer's disease (AD). However, its effect on cerebrospinal fluid (CSF) AD-biomarkers has not been investigated. We assessed cognitive performance and CSF AD-biomarkers, and potential moderation effect of bilingualism on the association between age, CSF AD-biomarkers, and cognition. Cognitively healthy middle-aged participants classified as monolinguals (n = 100, n CSF = 59), early (n = 81, n CSF = 55) and late bilinguals (n = 97, n CSF = 52) were evaluated. Models adjusted for confounders showed that bilinguals performed better than monolinguals on digits backwards (early-bilinguals p = 0.003), Judgment of Line Orientation (JLO) (early-bilinguals p = 0.018; late-bilinguals p = 0.004),...
全文获取路径: Elsevier  (合作)
影响因子:6.166 (2012)

  • cognition 认识
  • effect 效应
  • CSF Central Switching Facility
  • disease