Impact of rapid microbial identification directly from positive blood cultures using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry on patient management
作者: D. MartinyF. DebaugniesD. GateffM. GérardM. AounC. MartinD. KonopnickiA. LoizidouA. GeorgalaM. HainautM. ChantrenneA. DedisteO. VandenbergS. Van Praet
作者单位: 1Department of Microbiology, Saint-Pierre University Hospital and Jules Bordet Institute, Brussels, Belgium
2Hospital Pharmacy, Saint-Pierre University Hospital, Brussels, Belgium
3Division of Infectious Diseases, Saint-Pierre University Hospital, Brussels, Belgium
4Division of Infectious Diseases, Jules Bordet Institute, Brussels, Belgium
5Paediatric Department, Saint-Pierre University Hospital, Brussels, Belgium
6Infectious Diseases Epidemiological Unit, Public Health School, Université Libre de Bruxelles, Brussels, Belgium
刊名: Clinical Microbiology and Infection, 2013, Vol.19 (12), pp.E568-E581
来源数据库: Elsevier Journal
DOI: 10.1111/1469-0691.12282
关键词: Blood cultureclinical impactmatrix-assisted laser desorption/ionization time-of-flight mass spectrometryrapid diagnosissepsis
原始语种摘要: Abstract(#br)For septic patients, delaying the initiation of antimicrobial therapy or choosing an inappropriate antibiotic can considerably worsen their prognosis. This study evaluated the impact of rapid microbial identification (RMI) from positive blood cultures on the management of patients with suspected sepsis. During a 6-month period, RMI by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was performed for all new episodes of bacteraemia. For each patient, the infectious disease specialist was contacted and questioned about his therapeutic decisions made based on the Gram staining and the RMI. This information was collected to evaluate the number of RMIs that led to a therapeutic change or to a modification of the patient's general...
全文获取路径: Elsevier  (合作)
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