Alkaloids and biological activity of beribá ( Annona hypoglauca )
作者: Maria V.N. RinaldiIngrit E.C. DíazIvana B. SuffrediniPaulo R.H. Moreno
作者单位: 1Programa de Pós-graduação em Fármaco e Medicamento, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, SP, Brazil
2Núcleo de Pesquisas em Biodiversidade, Laboratório de Extração, Universidade Paulista, São Paulo, SP, Brazil
3Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil
刊名: Revista Brasileira de Farmacognosia, 2017, Vol.27 (1), pp.77-83
来源数据库: Elsevier Journal
DOI: 10.1016/j.bjp.2016.08.006
关键词: Annona hypoglaucaAntibacterial activityCytotoxicityIsoquinoline alkaloidsIsoboldineActinodaphnine
原始语种摘要: Abstract(#br)Annona hypoglauca Mart., Annonaceae, popularly known as “beribá”, was collected in flooded areas of the Amazonian Rain Forest. The crude extract obtained from this species was found to be cytotoxic against human cancer cells. Chemical information on A. hypoglauca is scarce. So, the present work aimed the isolation and identification of its alkaloids and to test their cytotoxic activity. Alkaloids were obtained from stem by acid–base partitioning and the remaining alkaloid-free extract was partitioned with organic solvents. Gas chromatography–mass spectrometry GC/MS analysis of total alkaloids allowed the identification of four aporphine alkaloids: actinodaphnine, anonaine, isoboldine and nornuciferine. Total alkaloids were fractionated by column chromatography and were...
全文获取路径: Elsevier  (合作)
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