α-Terpineol, a monoterpene alcohol, complexed with β-cyclodextrin exerts antihyperalgesic effect in animal model for fibromyalgia aided with docking study
作者: Makson G.B. OliveiraRenan G. BritoPriscila L. SantosHeitor G. Araújo-FilhoJullyana S.S. QuintansPaula P. MenezesMairim R. SerafiniYasmim M.B.G. CarvalhoJuliane C. SilvaJackson R.G.S. AlmeidaLuciana ScottiMarcus T. ScottiSaravanan ShanmugamParimelazhagan ThangarajAdriano A.S. AraújoLucindo J. Quintans-Júnior
作者单位: 1Department of Physiology, Federal University of Sergipe, Av. Tancredo Neves, S/N, Rosa Elza, São Cristóvão, Sergipe, CEP 49.000-100, Brazil
2Department of Pharmacy, Federal University of Sergipe, Av. Tancredo Neves, S/N, Rosa Elza, São Cristóvão, Sergipe, CEP 49.100-000, Brazil
3Department of Pharmacy, Federal University of San Francisco Valley, Petrolina, Pernambuco, CEP 56.304-917, Brazil
4Department of Chemistry, Federal University of Paraíba, João Pessoa, Paraíba, CEP 58051900, Brazil
5Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, 641 046, Tamil Nadu, India
刊名: Chemico-Biological Interactions, 2016, Vol.254 , pp.54-62
来源数据库: Elsevier Journal
DOI: 10.1016/j.cbi.2016.05.029
关键词: α-Terpineolβ-CyclodextrinFibromyalgiaChronic painPainOpioid
英文摘要: Abstract(#br)The anti-hyperalgesic effect of the complex containing α-terpineol (αTPN) and β-cyclodextrin (βCD) was analyzed in a non-inflammatory chronic muscle pain model, as well as its mechanism of action through docking study for a possible interaction with receptors. The αTPN-βCD complex was prepared and characterized through the thermogravimetry/derivate thermogravimetry (TG/DTG), Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM). The model of chronic muscle pain was induced by two injections of pH 4.0 saline (20 μl) into the left gastrocnemius 5 days apart. After confirming hyperalgesia, male mice were treated with αTPN-βCD (25, 50 or 100 mg/kg; p.o.) or vehicle (saline 0.9%, p.o.) daily for 10 days. 1 h after the mechanical hyperalgesia, motor...
全文获取路径: Elsevier  (合作)
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影响因子:2.967 (2012)

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