Pro-apoptotic effect of new quinolone 7- ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate on cervical cancer cell line HeLa alone/with UVA irradiation
作者: Soňa JantováNataša MrvováRoman HudecJán SedlákMiroslav PánikViktor Milata
作者单位: 1Institute of Biochemistry, Nutrition and Health Protection, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic
2Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovak Republic
3Cancer Research Institute, Slovak Academy of Science, Bratislava, Slovak Republic
4Institute of Management, Slovak University of Technology, Bratislava, Slovak Republic
5Institute of Organic Chemistry, Catalysis and Petrochemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic
刊名: Toxicology in Vitro, 2016, Vol.33 , pp.35-44
来源数据库: Elsevier Journal
DOI: 10.1016/j.tiv.2016.02.012
关键词: HeLa cellsQuinolone derivativeCell cycle arrestApoptosisUVA irradiation
英文摘要: Abstract(#br)7- ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate (E2 h ) is a new synthetically prepared quinolone derivative, which in our primary study showed cytotoxic effects towards tumor cells. The aim of the present study was to examine the antiproliferative and apoptosis inducing activities of E2 h towards human cervical cancer cell line HeLa with/without the presence of UVA irradiation. Further, the molecular mechanism involved in E2 h -induced apoptosis in HeLa cells was investigated. Our results showed that both non-photoactivated and photoactivated E2 h caused morphological changes and inhibited the cell growth of HeLa cells in a time- and dose-dependent manner. Irradiation increased the sensitivity of HeLa cells to E2 h . Quinolone induced S...
全文获取路径: Elsevier  (合作)
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影响因子:2.65 (2012)

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