Epithelial to mesenchymal transition in head and neck squamous cell carcinoma
作者: Ashley SmithTheodoros N. TeknosQuintin Pan
作者单位: 1Department of Otolaryngology – Head and Neck Surgery, Wexner Medical Center at Ohio State University, 442 Tzagournis Medical Research, 420 West 12th Avenue, Columbus, OH 43210, United States
2Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, United States
刊名: Oral Oncology, 2013, Vol.49 (4), pp.287-292
来源数据库: Elsevier Journal
DOI: 10.1016/j.oraloncology.2012.10.009
关键词: Head and neck cancerEpithelial to mesenchymal transitionE-CadherinVimentinInvasionMotility
英文摘要: Summary(#br)Epithelial to mesenchymal transition (EMT) is a dynamic cellular process that is essential for the development of metastatic disease. During EMT, a tumor cell with epithelial characteristics transitions to a tumor cell with mesenchymal characteristics through modulation of cell polarity and adhesion. Two hallmark EMT proteins, E-Cadherin and Vimentin, are tightly controlled during EMT through multiple signal transduction pathways. Epidermal growth factor (EGF) and transforming growth factorβ (TGFβ) promote EMT by regulating a distinct set of transcription factors, including Snail and Twist. Snail, Twist, and Slug are integral to the induction of EMT through direct regulation of genes involved in cellular adhesion, migration, and invasion. This review highlights the current...
全文获取路径: Elsevier  (合作)
影响因子:2.695 (2012)