Glomerular basement membrane alterations induced by gentamicin administration in rats
作者: Nenad StojiljkovicDragan MihailovicSlavimir VeljkovicMilan StoiljkovicIvan Jovanovic
作者单位: 1Department of Physiology, University of Nis School of Medicine, Nis, Serbia
2Department of Pathology, University of Nis School of Medicine, Nis, Serbia
3Department of Pharmacology and Toxicology, University of Nis School of Medicine, Bul. Zoran Djindjic 81, 18000 Nis, Serbia
4Department of Anatomy, University of Nis School of Medicine, Nis, Serbia
刊名: Experimental and Toxicologic Pathology, 2008, Vol.60 (1), pp.69-75
来源数据库: Elsevier Journal
DOI: 10.1016/j.etp.2008.02.007
关键词: GentamicinNephrotoxicityGlomerular basement membraneMorphometryRats
原始语种摘要: Abstract(#br)The widespread therapeutic use of the aminoglycoside antibiotic gentamicin (GM) is limited by its nephrotoxic side effect, which can lead to acute renal failure. This study aimed at examining effects of high, supratherapeutic doses of gentamicin on morphological, structural and functional alterations of the glomerular basement membrane in adult rats.(#br)Experiments were done on 30 male Wistar rats, divided into two experimental groups. GM-group (20 rats) received gentamicin at a dose of 100mg/kg intraperitoneally during eight consecutive days. Control or C-group (10 rats) received 1ml/day saline intraperitoneally. For histological analysis, 5μm thick sections were stained with hematoxylin and eosin (HE), periodic acid...
全文获取路径: Elsevier  (合作)
影响因子:2.622 (2012)