Glomerular basement membrane alterations induced by gentamicin administration in rats
| 作者： | Nenad Stojiljkovic, Dragan Mihailovic, Slavimir Veljkovic, Milan Stoiljkovic, Ivan Jovanovic |
| 作者单位： |
1Department of Physiology, University of Nis School of Medicine, Nis, Serbia 2Department of Pathology, University of Nis School of Medicine, Nis, Serbia 3Department of Pharmacology and Toxicology, University of Nis School of Medicine, Bul. Zoran Djindjic 81, 18000 Nis, Serbia 4Department of Anatomy, University of Nis School of Medicine, Nis, Serbia |
| 刊名： | Experimental and Toxicologic Pathology, 2008, Vol.60 (1), pp.69-75 |
| 来源数据库： | Elsevier Journal |
| DOI： | 10.1016/j.etp.2008.02.007 |
| 关键词： | Gentamicin; Nephrotoxicity; Glomerular basement membrane; Morphometry; Rats; |
| 原始语种摘要： |
Abstract(#br)The widespread therapeutic use of the aminoglycoside antibiotic gentamicin (GM) is limited by its nephrotoxic side effect, which can lead to acute renal failure. This study aimed at examining effects of high, supratherapeutic doses of gentamicin on morphological, structural and functional alterations of the glomerular basement membrane in adult rats.(#br)Experiments were done on 30 male Wistar rats, divided into two experimental groups. GM-group (20 rats) received gentamicin at a dose of 100 |
