Enhanced Expression of Glucose Transporter 1 on Erythrocyte Membrane in Hemodialysis Patients: The Possible Role in Erythrocyte Ascorbate Recycling
作者: Joseph G. WannChien-Sheng LinLi-Chien ChangYung-Ho HsuChiang-Ting ChienDeborah W. TaiJin-Shuen ChenChih-Ching YangLai-King YeungChau-Fong Chen
作者单位: 1Departments of Physiology and Medical Research, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei, Taiwan
2Department of Emergency and Critical Care, Cheng Hsin Rehabilitation Medical Center, Taipei, Taiwan
3School of Pharmacy, National Defense Medical Center, Taipei, Taiwan
4Divisions of Nephrology and Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan
5Department of Internal Medicine, Division of Nephrology, Tri-Service General Hospital, Taipei, Taiwan
6Division of Nephrology, Taipei City Hospital-Heping Branch, Taipei, Taiwan
7Department of Internal Medicine, College of Medicine, National Yang-Ming University, Taipei, Taiwan
8Department of Internal Medicine, Division of Nephrology, Cardinal Tien Hospital, Taipei, Taiwan
刊名: American Journal of Kidney Diseases, 2006, Vol.47 (6), pp.1055-1063
来源数据库: Elsevier Journal
DOI: 10.1053/j.ajkd.2006.02.190
关键词: Ascorbateerythrocyteglucose transporter 1hemodialysis (HD)
原始语种摘要: Background: Human erythrocytes can take up dehydroascorbate on the glucose transporter 1 (GLUT 1) and reduce it to ascorbate. Intraerythrocyte ascorbate was proved to be directly responsible for decreased oxidation of extraerythrocytic ascorbate. In addition to spontaneous and irreversible loss of ascorbate in plasma, the hemodialysis (HD) process itself consumes plasma ascorbate. However, intraerythrocyte ascorbate status in uremic patients during HD has yet to be reported. Methods: Plasma and intraerythrocyte ascorbate, dehydroascorbate, GLUT 1 expression on erythrocyte membranes, and in vitro studies of “erythrocyte ascorbate recycling” were investigated in age- and sex-matched healthy subjects (control group) and HD patients (HD group). Results: Intraerythrocyte ascorbate...
全文获取路径: Elsevier  (合作)
影响因子:5.294 (2012)