Liver X receptor (LXR) and the reproductive system – a potential novel target for therapeutic intervention
作者: Jerzy BełtowskiAndrzej Semczuk
作者单位: 1Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20-090 Lublin, Poland
2Second Department of Gynecology, Medical University, Jaczewskiego 8, PL 20-090 Lublin, Poland
刊名: Pharmacological Reports, 2010, Vol.62 (1), pp.15-27
来源数据库: Elsevier Journal
DOI: 10.1016/S1734-1140(10)70239-5
关键词: liver X receptorOxysterolsInfertilityovarian hyperstimulation syndromebreast cancerprostate cancer
原始语种摘要: Abstract(#br)Liver X receptor (LXR) α and β are ligand-activated transcription factors that regulate the expression of genes involved in the removal of cholesterol from cells by high-density lipoproteins, the transport of cholesterol to the liver and the biliary excretion of cholesterol. LXRs are activated by oxygenated cholesterol derivatives such as 24(S), 25-epoxycholesterol or 24(S)-, 25- and 27-hydroxy-cholesterol. In this review, we will discuss the role of LXR in the reproductive system and perspectives on the application of LXR agonists in the treatment of reproductive pathologies. Interestingly, progressive age-related impairment of fertility is observed in both female and male LXR knockout mice. Reduced fertility in female LXR knockout mice is associated with resistance to...
全文获取路径: Elsevier  (合作)
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影响因子:1.965 (2012)

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