Association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms with myocardial infarction in South Indian population
作者: Annan Sudarsan Arun KumarSrinivasamurthy Suresh KumarGurusamy UmamaheswaranRamasamy KesavanJayaraman BalachandarChandrasekaran Adithan
作者单位: 1Pharmacogenomics Laboratory, Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India
2Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India
刊名: Pharmacological Reports, 2015, Vol.67 (1), pp.97-101
来源数据库: Elsevier Journal
DOI: 10.1016/j.pharep.2014.08.010
关键词: CYP2C8CYP2C9CYP2J2Myocardial infarctionIndian
原始语种摘要: Abstract(#br)Background(#br)Cardiovascular diseases (CVDs) are the major cause of mortality and morbidity worldwide. Myocardial infarction (MI) is a complex multi-factorial, polygenic disorder arising from an interaction between genetic makeup of individuals and various environmental factors. CYP2C8, CYP2C9 and CYP2J2 gene involved in the metabolism of arachidonic acid, generates epoxyeicosatrienoic acids (EETs) that mediate dilation of coronary arteries improving post-ischemic cardiac contractile function, reduce vascular inflammation, and increase intravascular fibrinolysis. The study is aimed at analyzing the association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms and MI risk in the South Indian population.(#br)Methods(#br)This retrospective study consisted of 287 MI patients, 279...
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影响因子:1.965 (2012)

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