Protein N-linked homocysteine is associated with recurrence of venous thromboembolism
作者: Anastazja SzlauerAleksandra MielimonkaRafał GłowackiKamila BorowczykJustyna StachniukAnetta Undas
作者单位: 1Students' Scientific Association, Jagiellonian University Medical College, Krakow, Poland
2Department of Environmental Chemistry, University of Lodz, Lodz, Poland
3Institute of Cardiology, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland
刊名: Thrombosis Research, 2015, Vol.136 (5), pp.911-916
来源数据库: Elsevier Journal
DOI: 10.1016/j.thromres.2015.09.002
原始语种摘要: Abstract(#br)Background(#br)Recently, protein N-linked homocysteine (Hcy) has been measured in healthy subjects and patients with marked hyperhomocysteinemia. Since elevated total Hcy (tHcy) levels are associated with increased risk of venous thromboembolism (VTE), we aimed to investigate protein N-linked Hcy levels in patients with VTE.(#br)Methods(#br)We studied 200 consecutive patients with VTE (89 men, 111 women, aged from 17 to 83years), including 57 subjects with a subsequent episode of VTE (recurrent VTE) during 24months of follow-up. Protein N-linked Hcy was assayed using high-performance liquid chromatography with an on-column derivatization with o-phthaldialdehyde and fluorescence detection.(#br)Results(#br)The median protein N-linked Hcy...
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影响因子:3.133 (2012)

  • protein 蛋白质
  • associated 相关的
  • linked 连接的
  • homocysteine 同型胱氨酸
  • episode 
  • unprovoked 无端
  • recurrent 循环的
  • correlated 相关
  • predictor 预示
  • recurrence 循环