Bioreducible PAA- g -PEG graft micelles with high doxorubicin loading for targeted antitumor effect against mouse breast carcinoma
作者: Yong SunWen ZouShaoquan BianYihang HuangYanfei TanJie LiangYujiang FanXingdong Zhang
作者单位: 1National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu 610064, China
刊名: Biomaterials, 2013, Vol.34 (28), pp.6818-6828
来源数据库: Elsevier Journal
DOI: 10.1016/j.biomaterials.2013.05.032
关键词: MicellesReduction-responsiveDoxorubicinTumor targetingAntitumor
英文摘要: Abstract(#br)Nanomaterials have demonstrated to be promising to deliver a chemotherapeutic drug deeply into the tumor for improving the anticancer efficacy. In this study, eight kinds of bioreducible PAA- g -PEG graft copolymeric micelles were prepared, and the anticancer drug DOX was stably encapsulated in the micelles. Benefited by the hydrophobic interaction and π–π stacking between aromatic structure of DOX and phenyl of PAA in the micelle core, high drug loading content more than 50 wt/wt % could be achieved. Drugs released from micelles in a reduction-sensitive manner, and effectively inhibit the growth of 4T1 mouse breast cancer cells in vitro . In the 4T1 tumor-bearing nude mice breast carcinoma subcutaneous model, the DOX-incorporated micelles showed much stronger accumulation in...
全文获取路径: Elsevier  (合作)
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影响因子:7.604 (2012)

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