Estimation of linkage disequilibrium levels and haplotype block structure in Chinese Simmental and Wagyu beef cattle using high-density genotypes
作者: Hong NiuBo ZhuPeng GuoWengang ZhangJinglong XueYan ChenLupei ZhangHuijiang GaoXue GaoLingyang XuJunya Li
作者单位: 1Laboratory of Molecular Biology and Bovine Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China
刊名: Livestock Science, 2016, Vol.190 , pp.1-9
来源数据库: Elsevier Journal
DOI: 10.1016/j.livsci.2016.05.012
关键词: Linkage disequilibriumHaplotype blocksChinese Simmental beef cattleChinese Wagyu cattleHigH-density genotypes
原始语种摘要: Abstract(#br)With the advance of high-throughput genotyping technologies, it is possible to estimate the pattern of linkage disequilibrium (LD) and haplotype block structure at genome wide level in farm animals. Understanding LD characteristics and haplotype blocks can provide useful information to guide genome wide association study (GWAS) and genomic selection (GS). In this study, we investigated the LD pattern and haplotype block structure in two beef cattle populations (Chinese Simmental and Wagyu) using the BovineHD BeadChip. We found the average LD measured by r 2 in Chinese Wagyu was higher than that in Simmental. We observed LD decayed more slowly on the X chromosome than autosomes for both populations. The persistence of LD phase varied from 0.96 at a distance of <2.5...
全文获取路径: Elsevier  (合作)
影响因子:1.249 (2012)