Rheumatoid arthritis, insulin resistance, and diabetes
作者: Julia NicolauThierry LequerréHélène BacquetOlivier Vittecoq
作者单位: 1Service de rhumatologie, hôpital Charles-Nicolle, hôpitaux de Rouen, CHU, 76031 Rouen cedex, France
2Service de rhumatologie, Inserm 905, institut de recherche et d’innovation biomédicales, CIC/CRB1404, université de Rouen, hôpitaux de Rouen, CHU, 76031 Rouen cedex, France
3Service de médecine interne, hôpital de Dieppe, 76200 Dieppe, France
刊名: Joint Bone Spine, 2016
来源数据库: Elsevier Journal
DOI: 10.1016/j.jbspin.2016.09.001
关键词: Rheumatoid arthritisDiabetesInsulin resistanceTNFαIL-6IL-1βGlucocorticoids
原始语种摘要: Abstract(#br)Recent progress in the management of rheumatoid arthritis (RA) is turning attention toward comorbidities, such as diabetes. The objectives of this review are to clarify the links between RA and diabetes and to assess potential effects of disease-modifying antirheumatic drugs (DMARDs) on diabetes. The increased insulin resistance seen in RA is closely linked to the systemic inflammation induced by certain proinflammatory cytokines such as tumor necrosis factor α (TNFα) and interleukin-6. The prevalence of type 2 diabetes is increased in patients with RA. Furthermore, certain DMARDs including hydroxychloroquine, methotrexate, TNFα antagonist, and interleukin-1β antagonists seem to improve the markers of glucose metabolism. In contrast, glucocorticoids tend to adversely affect...
全文获取路径: Elsevier  (合作)
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影响因子:2.748 (2012)

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