Phosphorylated Epidermal Growth Factor Receptor Expression Is Associated With Clinicopathologic Parameters and Patient Survival in Mobile Tongue Squamous Cell Carcinoma
作者: Stamatios TheocharisConstantinos GiaginisEugene DanaIrene ThymaraJose RodriguezEfstratios PatsourisJerzy Klijanienko
作者单位: 1Associate Professor, Department of Pathology, Institute Curie, Paris, France; First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
2Assistant Professor, First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Department of Food Science and Nutrition, School of Environment, University of the Aegean, Lemnos, Greece
3Doctorate Candidate, First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
4Assistant Professor, First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
5Senior Researcher, Department of Pathology, Institute Curie, Paris, France
6Department Head, First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
刊名: Journal of Oral and Maxillofacial Surgery, 2016
来源数据库: Elsevier Journal
DOI: 10.1016/j.joms.2016.08.022
英文摘要: Purpose(#br)Phosphorylated epidermal growth factor receptor (pEGFR) activates several signaling pathways, resulting in tumor-promoting cellular activities, and has been implicated in malignant transformation and disease progression. The present study evaluated the clinical significance of pEGFR protein expression in mobile tongue squamous cell carcinoma (SCC).(#br)Materials and Methods(#br)The present cohort study included 48 patients with mobile tongue SCC. We evaluated whether pEGFR immunohistochemical protein expression is associated with clinical variables and patient outcome.(#br)Results(#br)Of the 48 patients included in the present cohort study, 25 were men and 23 were women. The median patient age was 60 years (interquartile range 53 to 72). pEGFR protein expression was...
全文获取路径: Elsevier  (合作)
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影响因子:1.333 (2012)

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