Point-, line-, and plane-shaped cellular constructs for 3D tissue assembly
作者: Yuya MorimotoAmy Y. HsiaoShoji Takeuchi
作者单位: 1Center for International Research on Integrative Biomedical Systems (CIBiS), Institute of Industrial Science (IIS), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan
2Takeuchi Biohybrid Innovation Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology (JST), Komaba Open Laboratory (KOL) Room M202, 4-6-1, Komaba, Meguro-ku, Tokyo 153–8904, Japan
刊名: Advanced Drug Delivery Reviews, 2015, Vol.95 , pp.29-39
来源数据库: Elsevier Journal
DOI: 10.1016/j.addr.2015.09.003
关键词: Microfluidic techniquesBottom-up tissue engineering3D tissue fabricationCellular building blocksClinical treatments
原始语种摘要: Abstract(#br)Microsized cellular constructs such as cellular aggregates and cell-laden hydrogel blocks are attractive cellular building blocks to reconstruct 3D macroscopic tissues with spatially ordered cells in bottom-up tissue engineering. In this regard, microfluidic techniques are remarkable methods to form microsized cellular constructs with high production rate and control of their shapes such as point, line, and plane. The fundamental shapes of the cellular constructs allow for the fabrication of larger arbitrary-shaped tissues by assembling them. This review introduces microfluidic formation methods of microsized cellular constructs and manipulation techniques to assemble them with control of their arrangements. Additionally, we show applications of the cellular constructs to...
全文获取路径: Elsevier  (合作)
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影响因子:12.888 (2012)

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