DNA methylation markers for oral pre-cancer progression: A critical review
作者: Krithiga ShridharGagandeep Kaur WaliaAastha AggarwalSmriti GulatiA.V. GeethaDorairaj PrabhakaranPreet K. DhillonPreetha Rajaraman
作者单位: 1Centre for Chronic Conditions and Injuries, Public Health Foundation of India, Gurgaon, Haryana, India
2Centre for Chronic Disease Control, Gurgaon, Haryana, India
3London School of Hygiene and Tropical Medicine, London, United Kingdom
4Center for Global Health, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
刊名: Oral Oncology, 2016, Vol.53 , pp.1-9
来源数据库: Elsevier Journal
DOI: 10.1016/j.oraloncology.2015.11.012
关键词: DNA methylationOral pre-cancerBio-markerEpigeneticsLeukoplakiaOral sub-mucous fibrosisPromoter regionsCpG sitesTumour suppressor genesDiagnostic marker
英文摘要: Summary(#br)Although oral cancers are generally preceded by a well-established pre-cancerous stage, there is a lack of well-defined clinical and morphological criteria to detect and signal progression from pre-cancer to malignant tumours. We conducted a critical review to summarize the evidence regarding aberrant DNA methylation patterns as a potential diagnostic biomarker predicting progression. We identified all relevant human studies published in English prior to 30th April 2015 that examined DNA methylation (%) in oral pre-cancer by searching PubMed, Web-of-Science and Embase databases using combined key-searches. Twenty-one studies (18-cross-sectional; 3-longitudinal) were eligible for inclusion in the review, with sample sizes ranging from 4 to 156 affected cases. Eligible studies...
全文获取路径: Elsevier  (合作)
影响因子:2.695 (2012)

  • methylation 甲基化酌
  • markers 时标
  • mucous 粘液的
  • fibrosis 纤维化
  • cancer 癌症
  • critical 临界的
  • review 复审
  • progression 级数
  • DNA Deoxyribonucleic Acid
  • suppressor 抑制栅