Erythropoietin attenuates experimental haemorrhagic shock-induced renal damage through an iNOS- dependent mechanism in male Wistar rats
作者: M. RanjbaranM. KadkhodaeeB. SeifiM. AdelipourB. Azarian
作者单位: 1Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2Department of Clinical Biochemistry, School of Medicine, Tarbiat Modares University, Tehran, Iran
3Protein Chemistry Lab, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
刊名: Injury, 2017, Vol.48 (2), pp.262-269
来源数据库: Elsevier Journal
DOI: 10.1016/j.injury.2017.01.010
关键词: KidneyHaemorrhagic shockResuscitationErythropoietinNOS inhibitor
原始语种摘要: Abstract(#br)Aim(#br)Erythropoietin (EPO) is shown to exert protective effects on different tissues in haemorrhagic shock (HS) states. Nitric oxide (NO), as a multifunctional signaling molecule, is implicated in diverse physiologic and pathologic processes. In order to understand the exact mechanism of EPO protection, in this study we evaluated the role of different NOS enzymes in the EPO signaling pathway in male rats.(#br)Methods(#br)Rats were randomized to five groups: 1) Sham, 2) HS 3) EPO 4) L-NAME, a non-specific NOS inhibitor 5) 1400W, a specific iNOS inhibitor. HS was induced by withdrawal of 50% of total blood volume. After 2h, resuscitation was performed with the shed blood and Ringer’s lactate. In group 3, rats were treated with EPO...
全文获取路径: Elsevier  (合作)
影响因子:1.931 (2012)

  • induced 感应的
  • renal 肾的
  • EPO Emergency Power Off
  • shock 冲击冲突
  • resuscitation 复苏
  • mechanism 机构
  • withdrawal 取消
  • beneficial 有利
  • damage 损伤
  • inhibitor 抑制剂