Enhancement of orofacial antinociceptive effect of carvacrol, a monoterpene present in oregano and thyme oils, by β-cyclodextrin inclusion complex in mice
作者: Juliane C. SilvaJackson R.G.S. AlmeidaJullyana S.S. QuintansRajiv Gandhi GopalsamySaravanan ShanmugamMairim Russo SerafiniMaria R.C. OliveiraBruno A.F. SilvaAnita O.B.P.B. MartinsFyama F. CastroIrwin R.A. MenezesHenrique D.M. CoutinhoRita C.M. OliveiraParimelazhagan ThangarajAdriano A.S. AraújoLucindo J. Quintans-Júnior
作者单位: 1Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, 56.304-205 Petrolina, Pernambuco, Brazil
2Department of Physiology (DFS), Federal University of Sergipe, 49.100-000 São Cristóvão, Sergipe, Brazil
3Department of Pharmacy (DFA), Federal University of Sergipe, 49.100-000 São Cristóvão, Sergipe, Brazil
4Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil
5Department of Biophysics and Physiology, Federal University of Piaui, 64.049-550 Teresina, PI, Brazil
6Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, 641 046, Tamil Nadu, India
刊名: Biomedicine & Pharmacotherapy, 2016, Vol.84 , pp.454-461
来源数据库: Elsevier Journal
DOI: 10.1016/j.biopha.2016.09.065
关键词: CarvacrolMonoterpeneCyclodextrinOrofacial painOpioidPain
原始语种摘要: Abstract(#br)Orofacial pain is associated with diagnosis of chronic pain of head, face, mouth, neck and all the intraoral structures. Carvacrol, a naturally occurring isoprenoid with diverse class of biological activities including anti-inflammatory, analgesic, antitumor and antioxidant properties. Now, the antinociceptive effect was studied in mice pretreatment with carvacrol (CARV) and β-cyclodextrin complex containing carvacrol (CARV-βCD) in formalin-, capsaicin-, and glutamate- induced orofacial nociception. Mice were pretreated with vehicle (0.9% Nacl, p.o. ), CARV (10 and 20mg/kg, p.o .), CARV-βCD (10 and 20mg/kg, p.o .) or MOR (10mg/kg, i.p .) before the nociceptive behavior induced by subcutaneous injections (s.c.) of...
全文获取路径: Elsevier  (合作)
影响因子:2.068 (2012)

  • carvacrol 香芹酚
  • by 
  • monoterpene 单萜
  • oregano 牛至
  • capsaicin 辣椒素
  • injections 用政府支出来刺激需求增长
  • cyclodextrin 环糊精
  • pretreatment 预处理
  • complex 超群
  • nociception 伤害感受